Life with MS & EDS

November 24, 2009

Cardiovascular Research

Filed under: Uncategorized — by mseds @ 2:54 pm
Tags: , , ,

I just read an interesting piece on some recent research that indicates there could be a cardiovascular component to Multiple Sclerosis and perhaps that MS isn’t an autoimmune disease after all.  I’m not quite sure what to think of this, although I do find it interesting.

Paolo Zamboni, a professor of medicine at the University of Ferrara in Italy, has a wife with MS.  He came up with a theory that excess iron can cause vein blockage.  His finding was that, “in more than 90 percent of people with multiple sclerosis, including his spouse, the veins draining blood from the brain were malformed or blocked. In people without MS, they were not.”

The excess iron can lead to inflammation and allow iron-damaged blood cells and other unwelcome cells to cross the brain-blood barrier.  By unblocking the vein (the procedure is similar to angioplasty), Dr. Zamboni treats the condition he calls “chronic cerebrospinal venous insufficiency.”  Fixing the drainage can treat and even prevent MS, he claims.


By unblocking the veins, he was able to eliminate most of his wife’s MS symptoms.  Others have had some success with this as well.  “The initial studies done in Italy were small but the outcomes were dramatic. In a group of 65 patients with relapsing-remitting MS (the most common form) who underwent surgery, the number of active lesions in the brain fell sharply, to 12 per cent from 50 per cent; in the two years after surgery, 73 per cent of patients had no symptoms.”

While this isn’t a large sample size, which causes me to be skeptical, it seems to warrants further research.  Has anyone else heard of this theory or about this research?  Does anyone happen to know if they are experiencing this kind of vein blockage, which is defined as chronic cerebrospinal venous insuffucuency (CCSVI)?

There’s additional information at the Multiple Sclerosis Resource Centre.



  1. Hi,

    I happened upon this post through Twitter: MS_Bloggers. FYI: Here’s a Canadian news story with more info about “The Liberation Treatment”. It’s television, and so clearly going for the heart, but there are some hard facts (and interview) in it you won’t find in the Globe and Mail article.


    Comment by Ron A. — November 24, 2009 @ 3:45 pm

  2. Consider that last post a drum roll. 🙂

    Comment by Ron A. — November 24, 2009 @ 3:49 pm

  3. Cool, thanks!

    Comment by mseds — November 24, 2009 @ 4:27 pm

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